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Acid Reflux Medication: What Works Best for You?

If heartburn keeps ruining your day, the right medication can change everything. Below we break down the most common acid reducers, easy‑to‑use OTC picks, and prescription swaps that actually help.

Top Over‑the‑Counter Choices

Most people start with a drug you can buy without a script. Antacids like Tums or Rolaids neutralize stomach acid fast, but they only work for a few hours. If you need longer relief, look at H2 blockers such as famotidine (Pepcid) or ranitidine (Zantac). They reduce acid production and last up to 12 hours.

For night‑time sufferers, a proton pump inhibitor (PPI) in low dose can be a game‑changer. OTC versions of omeprazole (Prilosec) or lansoprazole (Prevacid) keep the stomach quiet for 24 hours. Just remember they aren’t meant for daily use beyond a couple of weeks without doctor approval.

Prescription Alternatives You Might Consider

When OTC options fall short, doctors often prescribe stronger PPIs or combination drugs. If omeprazole isn’t right for you—maybe it caused headaches or didn’t calm your symptoms—there are seven solid alternatives:

  • Esomeprazole (Nexium): Similar to omeprazole but may work faster for some people.
  • Dexlansoprazole (Dexilant): Dual‑release formula covers both day and night reflux.
  • Pantoprazole (Protonix): Often used when other PPIs cause side effects.
  • Rabeprazole (Aciphex): Works well for patients with severe GERD.
  • H2 blocker combo: Adding famotidine to a low‑dose PPI can boost relief.
  • Sucralfate (Carafate): Coats the stomach lining; good if you can’t tolerate acid reducers.
  • Prokinetics like metoclopramide: Help the stomach empty faster, reducing reflux episodes.

All of these need a prescription, so talk to your doctor about dosage and how long you should stay on them. They’ll also check for interactions with other meds you might be taking.

Beyond pills, lifestyle tweaks boost any medication’s effect. Eat smaller meals, avoid lying down right after eating, and skip trigger foods like spicy dishes, caffeine, or chocolate. Elevating the head of your bed can stop nighttime reflux without extra drugs.

In short, start simple with an OTC antacid or low‑dose PPI. If symptoms linger, ask your doctor about one of the prescription alternatives listed above. Pair the right drug with a few easy habit changes, and you’ll likely see those burning feelings fade faster than you expect.

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