When working with exemestane, a steroidal aromatase inhibitor that lowers estrogen levels in hormone‑responsive breast cancer. Also known as Aromasin, it is prescribed mainly after menopause to help stop cancer growth.
As a member of the aromatase inhibitor class, these drugs block the enzyme aromatase, which converts androgens into estrogen, exemexestane cuts the main fuel for estrogen‑sensitive tumors. The drug binds permanently to the enzyme, making it a “suicide inhibitor” that offers steady estrogen suppression compared with reversible agents.
In the world of breast cancer, hormone‑positive tumors rely on estrogen to grow, so reducing estrogen is a key strategy. Exemestane is often chosen after the initial 5‑year tamoxifen course because it works well in post‑menopausal women. Compared to tamoxifen, which blocks estrogen receptors, exemestane lowers the actual hormone level, leading to different side‑effect profiles and sometimes better long‑term control.
Side effects matter as much as efficacy. Common issues include joint and muscle aches, hot flashes, and mild fatigue. Because estrogen also protects bone, long‑term use can raise osteoporosis risk; doctors usually pair exemestane with calcium and vitamin D supplements or a bisphosphonate. Managing these effects often means regular bone density scans and adjusting lifestyle factors like weight‑bearing exercise.
Practical concerns round out the picture. Many patients wonder if a cheaper generic version is safe—yes, as long as you order from a verified pharmacy and keep an eye on dosage consistency. Monitoring liver function tests is also standard, since exemestane is processed in the liver. Stay in touch with your oncologist about any new medications, herbs, or supplements, because interactions can alter hormone levels or liver enzymes. Below you’ll find a curated collection of articles that dive deeper into drug comparisons, buying guides, side‑effect management, and other hormone‑therapy topics—all aimed at helping you use exemestane safely and effectively.
A detailed comparison of Arimidex (anastrozole) with letrozole, exemestane, and tamoxifen, covering effectiveness, side effects, dosing, and how to choose the right option.